Event overview
The webinar will cover a series of topics including:
- Recent developments in exposure modelling include the U.S. EPA Office of Research and Development’s vision for exposure modelling (“computational exposure science”).
- Approaches to developing human health toxicity values - Approaches to developing human health toxicity values differ from country to country and even - as is the case with the Environment Agency Health Criteria Values and Defra's so called Low Levels of Toxicological Concern within a country. What is a cancer slope factor? And how do we convert a reference concentration to something we can use in CLEA? What did LQM use for the S4ULs? What did SoBRA use for their vapour GACs? And what is a benchmark dose anyway?
- Do we have a way to understand the dose response relationship on computers?
- Probabilistic modelling - Probabilistic modelling was built in to the original CLEA software but the Environment Agency moved to a deterministic model for deriving SGVs. Probabilistic methods allow uncertainty in input parameters to be taken into account when calculating exposure and when deriving Site Specific Assessment Criteria. The over conservatism created by using a combination of cautious input values will be explored.
- Mixtures – Many contaminants are encountered as mixtures and some always occur as mixtures. We will review what the regulatory and minesterial positions on contaminant mixtures are and what they mean for human health risk assessments.
- Acute risks - Acute risks were considered for cyanide in the first edition of the SNIFFER Method but no technical guidance was issued in the years when CLR reports were coming out. So how should acute risks be assessed?
- Does it matter which generic assessment criteria I choose to use for my site? What if my land use is not covered by any of them?
- What human health risk assessment models are practitioners using? And why is anything other than CLEA needed anyway?
- How can bioaccessibility testing be used to inform risk assessments?
- What can we do about assessing risks from emerging contaminants?
Timings: The webinar will start at 1pm (GMT), lasting 2 hours including Q&A
Special offer: book four or more webinars in the series and save 20%
